The role of biology in problems of thinking, feeling, and behaving

Pissing in the wind

It’s a new year, and I find myself living in a “post-fact” world of “fake news” with catastrophic failures of critical thinking everywhere on display. Happy New Year everybody! What holds true–if anything holds true these days–in the realm of politics is not fundamentally different from what holds true in other areas of discourse, like say, behavioral health. And that true thing is this: our current capacity for critical thinking cannot seem to adequately process, evaluate, and analyze the constant flow of information that is being channeled through structures designed to further agendas rather than deepen knowledge and improve understanding. That was a mouthful, I know. I just can’t help wondering though, Has all this blogging been just pissing in the wind? Have I myself been duped, or been duping myself, into a false sense of certainty and self-righteousness? Maybe. But at least I’m trying. At least I care enough to ask questions.

The first Friday of every month I attend a continuing education training for mental health professionals. The training takes place in a local psychiatric hospital, and is conducted by various local leaders in the mental health profession. This last training was on the topic of addiction treatment, and I was expecting to get a heavy dose of twelve-step and brain disease dogmatism, and that’s just what happened. What took me by surprise was how starkly unscientific the presentation was–not a single reference to a single piece of research, and how uncritical the audience was as they nodded their heads to statements like “This disease wants you dead!” I felt like I was in a church listening to a sermon. I left the training deflated and discouraged. How can there be any hope of a sane, scientifically grounded approach to drug abuse (or any mental health problem for that matter) when the thought leaders, experts, and armies of professionals are all in lock-step headed in the wrong direction? Fortunately, there are dissident voices breaking through via the internet ether waves. But again, perhaps I have constructed my own cozy echo-chamber in this regard. You be the judge.

Johann Hari, he of “Chasing the Scream” and TED notoriety, wrote an interesting op-ed in the LA Times the other day called “What’s really causing the prescription drug crisis?” The piece pokes holes in the most well-subscribed narrative regarding the current opiate crisis in America, namely that Big Pharma has hooked everyone on irresistible drugs, and that what we need to do now is restrict access to these powerful life-ruining substances. The holes in this theory might not seem obvious. Even John Oliver, whose entertaining critiques usually strike the right tone, seems to have blown past them.

First of all, Hari points out that less than one percent of opiate prescriptions lead to addiction, and that super strong opiates (like diamorphine) are routinely administered in hospital settings in other countries without causing people to become addicted. So, then, the drugs themselves can’t be root of the problem, right? If it were the drugs themselves, then opiate addiction should be spread evenly across the country to match prescription rates. But it isn’t. Opiate addiction is concentrated in areas where times are the toughest, like in the Rust Belt. It’s the tough times–and their impact on people who may lack the resources (internal and external) to cope with them–that are more likely to be the root of the problem, rather than any specific numbing agent. Furthermore, how can stringent opiate restriction be the best response to the problem, when the vast majority of people who use the drugs to manage pain don’t show problematic use, and when cutting addicted folks off from their prescriptions so clearly leads them to black market heroin use? This “War on Drugs” mentality might be well-intentioned, but it’s just making things worse. In order to come up with a more effective solution, we need to fully understand the problem, which means taking into account all of the facts, which would lead us toward addressing root causes (like poverty, social isolation, poor coping skills) instead of restricting the latest, most available, most potent means of killing the associated pain.

Of course, addiction is just one category of so-called “mental illness,” and a broader argument can (and has) been made against viewing problems of thinking, feeling, and behaving, in general, as biologically driven processes best suited for physiologically focused interventions. I have been pissing in that wind for years as well, but I have not come across a more thorough critique of the predominant psychiatric paradigm than in this recent article by Phil Hickey called The Biological Evidence for “Mental Illness.” Hickey makes many of the points that I have made–ad nauseam–in previous posts (e.g., HERE), but he makes them far more meticulously and convincingly. He also grounds his arguments in research and years of clinical experience. Here are a few of Hickey’s ideas from this article that are well worth chewing on:

Depression, either mild or severe, transient or lasting, is not a pathological condition. It is the natural, appropriate, and adaptive response when a feeling-capable organism confronts an adverse event or circumstance. And the only sensible and effective way to ameliorate depression is to deal appropriately and constructively with the depressing situation. Misguided tampering with the person’s feeling apparatus is analogous to deliberately damaging a person’s hearing because he is upset by the noise pollution in his neighborhood, or damaging his eyesight because of complaints about litter in the street.

What psychiatry calls mental illnesses are actually nothing more than loose collections of vaguely-defined problems of thinking, feeling, and/or behaving. In most cases the “diagnosis” is polythetic (five out of nine, four out of six, etc.), so the labels aren’t coherent entities of any sort, let alone illnesses. But the problems set out in the so-called symptom lists are real problems. That’s not the issue. I refer to these labels as inventions, because of psychiatry’s assertion that the loose clusters of problems are real diseases. In reality, they are not genuine diseases; they are inventions. They are not discovered in nature, but rather are voted into existence by APA committees.

Both Hari and Hickey hit the nail on the head by pointing out what should be obvious, namely that addiction and other psychological problems are most often matters of adaptation, of learning, which are process that all healthy, normal brains participate in as they interact with their respective environments. How else could it be that the vast majority of people with such problems get better through such means as talking things out, rearranging their priorities, determination to change habits, and improving relationships? While it’s true–again, obviously–that every subjective human experience is grounded in some activity happening in the brain from moment to moment, it is sheer nonsense to assume that common problems faced by vast numbers of human beings are matters of hardware malfunction. This might be true for the very few. But it is only through misaligned incentives and misapplied critical thinking that the brain disease paradigm has become mental health dogma.

*Mic drop*

Addictionally irrational

Go to the National Institute on Drug Abuse (NIDA) website right now and you’ll see brains. Pictures, graphics, scans — a colorful display. You’ll also see a photo of Nora Volkow, NIDA’s director, whose “work has been instrumental in demonstrating that drug addiction is a disease of the human brain.” This would be all well and good, if pictures (or any other representation or analysis) of what’s going on in a drug user’s brain actually demonstrated that addiction is a brain disease. But they don’t. How it is that “we have come to believe” this irrational notion, that it has become the accepted truth among both lay people and professional orthodoxy, is simply mind-boggling to me.

As Stanton Peele has pointed out again and again, including today on his Psychology Today blog, the brain disease model of addiction defies both common sense and a reasonable interpretation of scientific research:

The chronic brain disease model doesn’t explain the most fundamental things about addiction, like how the vast majority of people overcome it without treatment, that there are no measurable biological means to determine whether and when people are addicted and when they are not, nor is there any treatment that addresses the supposed dopamine-based nature of addiction. In fact, the best science and therapy both point towards an entirely opposite, real-world way of defining “recovery.”

Meanwhile, as the idea of addiction as a brain disease is imbedded in our culture, we simply get more and more examples of brain diseases as more and more things are understood as addictions, and as we spread the idea further and thinner than any possibly scientific explanation can be spread.

This idea is not an expression of science. It is, instead, a cultural myth, one that the best and the brightest are obligated to endorse to be recognized as mainstream thinkers.

Don’t get me wrong — I’m all for learning as much as possible about the physiological and neurological aspects of addiction, and of all other realms of human experience for that matter. Of course brains (our organism/physiology in general) are absolutely foundational to all that we experience. A baseball bat to the head is all the evidence needed to establish that fact. But how, pray tell, does the plainly evident and obvious fact that all human experience is grounded and reflected in wonderfully complex and interesting ways in the brain and body lead to the notion that so many of our life problems are therefore fundamentally diseases of the brain? Imagine Nora Volkow’s perfect scenario, that after years of research we have finally and perfectly mapped all the changes that happen in the brain over the complete course of drug use and addiction. Imagine that brain scan technology could yield perfect scans and that we understood and interpreted the images perfectly. To my mind that still wouldn’t lend a shred of evidence to the notion that addiction is a brain disease.

A quick thought experiment: You are hooked up to this hypothetical machine (a super scanner) which can perfectly record all changes in your body’s and brain’s physiology, demonstrating with perfect accuracy every deviation from healthy homeostasis. You are put in room. In through the door on the far end walks a tiger. Your body and brain begin to go haywire. Hormones and neurotransmitters are sloshing around and completely transform your state of existence from one of total health and relaxation to one of total stress. The super scanner perfectly records every change and quickly prints out a recipe for a drug that will re-balance your system, with minimal side effects. While your state of stress and imbalance is clearly and dramatically grounded and reflected in your physiology, isn’t it a bit shortsighted to think of your problem solely or even primarily in those terms? If someone were to drop a cage on the tiger, your physiology would quickly and naturally move back to homeostasis without any need for a drug or any other physiological intervention. Your problem was primarily the presence of the tiger, not the changes in your brain that the presence of the tiger inspired. The solution–i.e. the appropriate intervention–to the problem was primarily social and behavioral, not physiological. In fact, the information provided by the super scanner, interesting as it might be, was completely irrelevant in terms of the practical solution to the problem.

Drug use and abuse changes what’s going on in the brain. Yes. Everything we do and everything that happens to us changes what goes on in the brain. Yes. Therefore, deviations from healthy, homeostatic brain and body states are best thought of as diseases of the brain? Not so fast Dr. Volkow. Studying objective brain changes is one of many perspectives that are worthy of consideration, focus, and scrutiny. Taken together with subjective, relational, behavioral, social, and cultural perspectives, we might yet arrive at a truly comprehensive, rational, integral approach to helping those seeking health and well-being.